| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication and Characterization of PLGA/Pluronic F127 Embedded PCL Electrospun Sheet for Effective Guided Bone Regeneration |
| 초록 |
Bone healing is one of the importance phenomena in various clinical fields. The rapid appearance of fibrous connective tissue in bone defect during the healing, which can lead to the incomplete bone formation, has been considered as a major problem. To solve this, guided bone regeneration (GBR) membranes which can prevent fibrous connective tissue infiltration and thus promote bone healing have been used as a simple therapy. In this study, we fabricated a novel GBR membrane by the immersion precipitation of PCL electrospun sheet filled with PLGA/Pluronic F127 solution. The prepared GBR membrane was expected to have selective permeability, flexibility and mechanical strength, which can provide good environment for bone regeneration as well as surgical facility. The morphology, mechanical strength (tensile and suture tests), and model nutrient permeability of the GBR membrane were investigated. Preliminary animal study using a rat model (skull bone defect) was also carried out. |
| 저자 |
김준호1, 조완진1, 오세행1, 김진만2, 이진호1
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| 소속 |
1한남대, 2충남대 |
| 키워드 |
Guided bone regeneration; Electrospun sheet; Biodegradable polymers
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| E-Mail |
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