| 초록 |
Double-network (DN) hydrogels have recently received considerable attention because of their superior mechanical properties. However, the fabrication of injectable DN hydrogels remains a challenging task for biomedical use. In this study, in situ forming DN hydrogels composed of acrylamide (AAm) and 4-arm-PPO-PEO-tyramine (TTA) were prepared by simple mixing an aqueous AAm/TTA solution with Fenton’s reagents in the presence of horseradish peroxidase. The gelation time and mechanical properties of DN hydrogels could be easily manipulated by varying the concentration of Fenton’s reagents. The resulting DN hydrogel exhibited improved compressive strength over 2 MPa, which was almost 3-5 times higher than those of single network hydrogels. In addition, it appeared that the DN hydrogels were not cytotoxic. Our results demonstrate that the tough DN hydrogels via enzymatic cross-linking and Fenton reactions can be useful for various injectable biomedical applications. |
