| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-콜로이드·계면화학 |
| 제목 |
Supported lipid membrane platform technology for anti-infective applications |
| 초록 |
We demonstrate that adding mixtures of lauric acid (LA) and glycerol monolaurate (GML) – two of the most biologically active antimicrobial fatty acids and monoglycerides – to a supported lipid bilayer platform triggers concurrent tubule and bud formation, which unexpectedly results in synergistic phospholipid membrane remodeling that far exceeds the effects of GML or LA alone. The most pronounced effects occurred with equimolar concentrations of GML and LA in the micellar state, highlighting that synergistic membrane disruption and an inability to relieve membrane strains. These findings offer a new model to explain how fatty acid and monoglyceride interactions can trigger phospholipid membrane remodeling events relevant to various biophysical and biological systems. |
| 저자 |
윤보경, 문수지, Joshua A. Jackman
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| 소속 |
성균관대 |
| 키워드 |
supported lipid bilayer; biosensing; self-assembly; micelle
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| E-Mail |
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