| 초록 |
Upconversion nanoparticles (UCNPs), have the ability to convert near infrared radiations with lower energy into visible radiations with higher energy via a nonlinear optical process. UCNPs is a substance that can activate adjacent photosensitizer (PS) for photodynamic therapy (PDT) through fluorescence resonance energy transfer. in addition, these UCNPs have advantages such as minimum photodamage to living organisms, weak background fluorescence, high detection sensitivity, and high light-penetration depth in tissues. In this study, UCNPs were synthesized under various conditions by thermal decomposition method to investigate the photoluminescence efficiency according to size and shape. Their surface modification was conducted for PDT application. Finally, PDT action of surface-modified UCNPs were determined by singlet oxygen generation with 980 nm NIR laser. |
