| 학회 |
한국화학공학회 |
| 학술대회 |
2021년 가을 (10/27 ~ 10/29, 광주 김대중컨벤션센터) |
| 권호 |
27권 2호, p.1701 |
| 발표분야 |
생물화공 |
| 제목 |
Metabolic engineering for the fermentative production of aromatic polyesters |
| 초록 |
Escherichia coli strains developed in this study is able to produce aromatic polyesters from glucose through one-step fermentation. Here, Clostridium difficile isocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase and evolved polyhydroxyalkanoate synthase genes are expressed in a engineered D-phenyllactate-overproducer strain. Poly(3-hydroxybutryate-co-D-phenyllactate) copolymers, with different molar compositions are produced through expression of Cupriavidus necator β-ketothiolase and reductase genes. This is the first attempt on the one-step fermentative production of aromatic polyesters from renewable resources. [This work was supported by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) and also by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF2012M1A2A2026556 and NRF-2012M1A2A2026557) from the Ministry of Science and ICT through the National Research Foundation of Korea.] |
| 저자 |
이영준1, 양정은2, 박시재3, 김원준4, 김형준1, 김범준1, 이혁5, 신지훈5, 이상엽1
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| 소속 |
1KAIST, 2한국김치(연), 3이화여자대, 4한화케미칼, 5한국화학(연) |
| 키워드 |
생물화학공학 |
| E-Mail |
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| 원문파일 |
초록 보기 |
