| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.373 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis of Liposome Containing Specific Functional Site |
| 초록 | In order to develop targeting drug delivery system, we synthesized liposome containing specific functional site. For the aim of this study, we prepared a phosphatidyl ethanol amine lipid with biotin (PEB) as specific functional site and also fabricated the liposome consisted of the lipid (PEB), hydrogenated soy phosphatidylcholine (HSPC), cholesterol. For characterization of the synthesized liposome branched with biotin, NMR, IR and DLS were applied in this study. Particle size of the liposome with biotin as functional site was around 200 ㎚. To identify the attachment of specific antibody on liposome branched with biotin, we added the avidin-FITC as model target site. The liposome showed the fluorescence after purification, indicating the interaction of biotin-avidine. Acknowledgement: This work was supported by KK-0302-BO. |
| 저자 | 길희주1, 이진수2, 서광수2, 육순홍1, 강길선2, 신병철3, 김승수3, 김문석3, 이해방3, 조선행3 |
| 소속 | 1한남대, 2전북대, 3한국화학(연) |
| 키워드 | liposome; biotin |
