| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Synthesis of PEG-b-Poly(L-lysine-co-L-Phenylalanine)s Conjugated with L-Arginine and Histidine as a Non-viral Gene Delivery Vector |
| 초록 |
Natural and synthetic polycations displaying non-pathogenic and non-immunogenic properties have been employed as non-viral vectors for gene delivery due to the safety concerns. The main obstacle in gene therapy is the development of efficient, non-toxic delivery carriers, which effectively transport DNA inside the cell nucleus of the target. Lysine based amino acid copolymers containing 30 molar % of phenylalanine residues were prepared with α-methoxy-ω-aminopoly(ethylene glycol) block at one end. Primary amino groups in the side chain of lysine residues were conjugated with L-arginine in almost quantitative yields. PEG-b-Poly(L-lysine-co-L-Phenylalanine)s conjugated with histidine derivatives were also prepared and their transfection efficiency as well as cytotoxicity were tested to investigate the role of the copolymers as an endosomal escape moieties. Obtained copolymers were applied as a gene delivery carrier and the selective targeted delivery to the neuron cells were tested. |
| 저자 |
임미정1, 안철희1, 이민형2
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| 소속 |
1서울대, 2한양대 |
| 키워드 |
Non-viral Gene Delivery carrier; PEG-b-Poly(L-lysine-co-L-Phenylalanine)s Conjugated with L-Arginine; PEG-b-Poly(L-lysine-co-L-Phenylalanine)s Conjugated with Histidine
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| E-Mail |
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