| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis of Novel Biocompatible Zwitterionic PEG for Peripheral Arterial Stents |
| 초록 | Stent placement is an accepted treatment for peripheral vascular occlusive disease.1 However, long-term success of this procedure is still limited by development of chronic in-stent restenosis due to neointimal hyperplasia, which occurs in up to 40% of all patients who received stent placement in peripheral arteries.2 The basic requirements of peripheral arterial stents are biocompatibility, metallurgic properties, high radio-opacity, and physical properties. Among them, biocompatibility is one of the crucial factor for long-term applications. In order to develop better blood compatible materials, a vast number of researches have been directed toward chemical modification. In general, poly(ethylene glycol) (PEG) was reported to be more blood compatible due to the steric stabilization and chain motion effects. In addition, sulfobetaines (-N+-SO3-) have recently received increased attention to one of the biocompatible structures in the well-identified class of zwitterionic polymer materials. Because of the strongly dipolar structure of their zwitterionic lateral groups, these linear polymers display specific properties such as high chain rigidity and very unusual and unique antipolyelectrolyte behaviours. In this study, novel biocompatible zwitterionic PEG (PEG-N+-SO3-) was successfully synthesized from PEG through three reactive steps. The chemical structures of each reaction step were confirmed by FTIR, NMR, and GPC (Fig. 1). Fig. 1. FTIR spectra of PEG derivatives. References 1. G. Ramaswami and M.L. Marin., Surg. Clin. North. Am., 79, 597-609 (1999). 2. S. Rosanio, M. Tocchi, B.F. Uretsky, and G.A. Stouffe., Am. J. Med. Sci., 319, 111-117 (2000). |
| 저자 | 김재훈1, 서지수1, 안광덕1, 김종만2, 한동근1 |
| 소속 | 1한국과학기술(연), 2한양대 |
| 키워드 | Peripheral arterial stents; Biocompatibility; Zwitterionic PEG |
