| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
A novel cationic moiety incorporated PLGA nanocapsules for Transdermal drug delivery |
| 초록 |
In order to improve the skin permeability of negatively charged drugs like genistein, the cationic moiety incorporated polymer nanocapsules were suggested as a drug carrier. Negatively charged drugs were successfully loaded in the nanocapsules by ionic conjugation between negatively charged drugs and incorporated cationic groups. The genistein loaded poly(D,L-lactide-co-glycolide) (PLGA) nanocapsules were effectively penetrated through the skin without causing side effects. Size and morphology of nanoparticles, genistein loading efficiency, a quantity of amine, toxicity of aminated PLGA, the In-vitro drug release, and zeta potential were investigated. In-vitro and In-vivo skin penetration tests were also carried out to demonstrate the improved skin permeability of the genistein loaded PLGA nanocapsules. |
| 저자 |
신진섭1, 남정범1, 정재은1, 강선웅1, 신교민1, 한주현1, 류지현1, 김병수1, 서경도1, 김용진2, 김진웅2
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| 소속 |
1한양대, 2(주)아모레퍼시픽 |
| 키워드 |
Transdermal drug delivery; nanocapsules; PLGA; genistein
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| E-Mail |
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