| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Attenuated responses& behaviors of vascular smooth muscle cells onto catechin-eluting stent coatings and action mechanisms of eluted catechin |
| 초록 |
The suppressive effects of epigallocatechin gallate (EGCG) eluted from poly(lactide-co-ε-caprolactone, PLCL) stent coatings were investigated on the responses and behaviors of vascular smooth muscle cells (VSMCs). The involvement of nuclear factor-κB (NF-κB) was also examined as the mechanisms of EGCG-mediated inhibition. The proliferation and migration of VSMCs onto EGCG-eluting PLCL were significantly inhibited. VSMC cultures onto EGCG-eluting PLCL resulted in induction of cell cycle arrest at G0/G1 phase, leading to subsequent apoptosis. Expression of active matrix metalloproteinase-2 was directly lowered by EGCG and indirectly inhibited by EGCG-mediated suppression of NF-κB. Here were found the incorporation of FITC-conjugated EGCG into the cytosol of VSMCs and its further nuclear translocation. Taken together, the attenuated responses of VSMCs onto EGCG-eluting stent coatings was shown to be mediated through the suppression of NF-κB by EGCG incorporated into the cells. |
| 저자 |
한동욱1, Han Hee Cho2, Kazuaki Matsumura3, Suong-Hyu Hyon2
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| 소속 |
1부산대, 2Kyoto Univ., 3Institute for Frontier Medical Sciences |
| 키워드 |
Epigallocatechin gallate; Poly(lactide-co-ε-caprolactone); Vascular smooth muscle cells; Matrix metalloproteinase-2; Nuclear factor-κB
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| E-Mail |
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