| 초록 |
This study demonstrates synergetic effects of nitric oxide (NO) and hydrogen sulfide (H2S) as physiological modulator in vivo. NO is endogenously produced by nitric oxide synthase and convert GTP to cGMP stimulating protein kinase G (PKG) which regulate physiological functions such as angiogenesis and vasodilation through activating ion channels. Similarly, H2S involves in this signaling cascade. H2S can inhibit PDE5A that can degrade cGMP. By inhibiting degradation of cGMP, NO signals could be ultimately amplified by H2S. In this study we propose Co-delivery system with NO and H2S, by biocompatible and biodegradable polymers; mPEG-PLGA. The NO donating moiety, S-nitrosothiol, is conjugated on the hydrophobic (PLGA) end and H2S is released from polymeric nanocarriers containing H2S donor. NO generating moiety release NO triggered by thermal and photo (NIR) sources. We suggest that the mPEG-PLGA-SNO nanoparticle can release NO and H2S in controlled manner for signal amplification. |
