| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Nano-Bio Functionalized Polymer Platforms for Controlling Human Breast Metastatic Cancer Cell Behavior |
| 초록 |
In the present study, we investigate the effect of the inclusion of protein-modified gold nanoparticles in polymer matrices on the behavior of human breast cancer cells. The human breast epithelial metastatic cancerous cells (CAMA-1) have been cultured and analyzed on the polymer films containing gold nanoparticles coated with different proteins. Poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) were employed as the basic building blocks for polyelectrolyte matrices and two different proteins (fibronectin and ephrin) were introduced for the surface modification of gold nanoparticles. The surface roughness as well as bio-recognition feature of the polymer matrices was varied by either coating different proteins on the polymer surface or incorporating protein-grafted gold nanoparticles on flat polymer substrates. Cellular phenotypic changes were analyzed in terms of adhesion, morphology, and cytoskeletal organization on different polymer matrices. |
| 저자 |
서진화, 이효진, 남좌민, 차국헌
|
| 소속 |
서울대 |
| 키워드 |
polymer platform; metastatic cancer; cell adhesion
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| E-Mail |
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