| 초록 |
Hydroxyapatite (HAp) is a major bone graft ingredient for hard tissue regeneration. However, sintered HAp has poor mechanical properties and difficulty for cell adhesion and proliferation with irregular pore structures. Porous 3D scaffolds for hard tissue regeneration were fabricated by mixing poly(glycolic acid) (PGA) and HAp using a 3D printer. This method can induce improved bone conduction ability with similar mechanical strength. Through the cell proliferation test, PGA/HAp scaffolds with a 400 μm pore size were accepted. PGA scaffolds containing 12.5 wt% HAp showed significant compressive strength, osteogenesis, mineralization and biodegradation. In in vivo animal test using rabbit calvarial defect model, the PGA/HAp scaffolds exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. This method was useful tool for hard tissue engineering application. |
