| 초록 |
Isoprenoids, also called terpenoids, are a large and diverse class of naturally-occurring compounds. They are present in all living organisms and include many important drugs, valuable flavor and fragrance compounds, pigments, antioxidants, steroids and natural polymers. However, most of valuable isoprenoids are produced in a trace amount as secondary metabolites from intractable slow growing organisms such as plants, actinomycetes, archaea, etc. Isoprenoids are derived from five-carbon universal building blocks assembled and modified in various ways. The increased synthesis of building blocks of IPP and DMAPP through metabolic redesign is a way to enhance the production of isoprenoids. This work is supported by a grant (NRF-2013R1A1A2008289) and a grant (NRF-2012M1A2A2671831) from the National Research Foundation, MSIP, and a grant from the Next-Generation BioGreen21 Program (SSAC, grant#: PJ01106201), RDA, Korea. |
