| 초록 |
Magnetic resonance imaging (MRI) is a high-resolution and clinically important imaging modality, which offers anatomical information, enabling diagnosis and prognosis of disease. We developed distance-dependent magnetic resonance tuning (MRET), which occurs between a paramagnetic 'enhancer' and a superparamagnetic 'quencher', where the T1 magnetic resonance imaging (MRI) signal is tuned ON or OFF depending on the separation distance between the quencher and the enhancer. With MRET, we demonstrate the successful detection of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitro. |
