| 초록 |
PDT, a clinical therapeutic modality, has great potential to become an efficient theranostic approach for noninvasive treatment of tumors. However, a major drawback in the current therapy is the limited penetration depth due to the light absorption and scattering by biological tissues, resulting in ineffective therapeutic effects. For deep penetration of light into tissues, the wavelength of the irradiated beam should be in the near-infrared (NIR) window (700-1100 nm). Recently, the upconversion nanoparticles (UCNPs) opened a new gate for full utilization of currently commercial available PS upon NIR irradiation. In our study, UCNPs with hexagonal phase were synthesized by hydrothermal method. Then, FA-conjugated biocompatible block copolymers were employed to improve their solubility and stability. High efficient commercial PSs were also conjugated to the stable UCNPs. The composition, optical property and morphology of UCNP-based nanomedicine were investigated. |
