| 초록 |
The natural, indiscrete bone-to-tendon region has a gradient in structure and composition, which is translated into a spatial variation of chemical, physical, and biological properties. This unique transitional tissue between tendon and bone is not normally recreated during natural tendon-to-bone healing. Thus, it is critical to develop a scaffold with a controllable gradation in structure and composition. We have developed gradient scaffolds consists of (i) an upper layer of collagen, mimicking the tendon region, (ii) an intermediate layer of partially mineralized collagen, resembling the fibrocartilage region, (iii) a lower layer of mineralized collagen with a high extent of minerals, corresponding to the subchondral bone. The biomimetic and multiphasic design coupled with a spatial control of cell distribution may enable multi-tissue regeneration on the stratified scaffold, and thus be potentially used for regeneration of the interface between soft tissue grafts and bone. |
