| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.380 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Degradation behavior in vitro for vacuum-dried poly(D,L-lactide-co-glycolide) |
| 초록 | Biodegradable polymers such as poly lactide (PLA), poly glycolide (PGA) and poly (D, L-lactide-co-glycolide) (PLGA) have been extensively investigated because of easily controlled drug release rate, completely degradable materials without the toxic by-product and good biocompatibility. Among the biodegradable polymers currently under investigation, PLGA copolymers are the most widely studied because of their long history of safe clinical use as drug carrier. But PLGA has bulk erosion property1 which have first-order release reduced release amount slowly after excessive initial burst2 in vitro test. In this study, PLGA powders are obtained through recrystallization to revise bulk erosion property of PLGA. Then, prepared PLGA powder by vacuum-dry was fabricated to wafers for estimate release profiles of BCNU. Moreover, we are performed that degradation tests such as water absorption, mass loss and pH change of media to evaluate of hydrophilic additives effect. Figure 1 showd the drug release profiles for non-treated and vacuum-dried PLGA wafer. The initial burst of BCNU used vacuum-dried PLGA wafer was lower than non-treated PLGA wafer and drug release rate is maintained continuously. Beside, vacuum-dried PLGA wafer was decreased water penetrate into the wafer (Figure 2). In these results, we supposed that vacuum-dried PLGA wafer has surface erosion property. Acknowledgement: This work was supported by KMOCIE(B49-990-5411-05-1-3). Reference 1. F. v. Burkersroda, L. Schedl, A. Gopferich, Biomaals., 23, 4221 (2002). 2. J. S. Lee, G. S. Chae, T. K. An, G. Khang, S. H. Cho, H. B. Lee, Macromol. Res., 11 (3), 183 (2003). |
| 저자 | 채강수1, 전세강2, 김종민2, 조선행1, 강길선2, 이해방1 |
| 소속 | 1한국화학(연), 2전북대 |
| 키워드 | PLGA; BCNU; Wafer; Vacuum dry method |
