| 초록 |
We developed a series of dual-ionic pH-sensitive poly(urethane amino sulfamethazine)-based random copolymer for the controlled release of various therapeutic agents. Poly(urethane amino sulfamethazine) exhibited a dual ionic pH-sensitive property in an aqueous solution. At high pH (~pH 8.5), the copolymer exhibited a negative charge and was water soluble due to the sulfamethazine groups. On the other hand, at low pH (~pH 5.0), the copolymer transformed to cationic due to the ionization of tertiary amine groups. Interestingly, at the physiological condition (pH 7.4), the copolymer could form a particulate structure and encapsulate protein/drugs effectively via the ionic and hydrophobic interaction between polymer and protein/drugs. The dual-ionic pH-sensitive characteristics of the copolymers were used in the controlled delivery of protein/drugs to treat various intractable diseases. At last there will be a small touch for forty years research history of Doo Sung Lee. |
