| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 가을 (10/28 ~ 10/29, 건국대학교) |
| 권호 |
9권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
Asymmetric Synthesis of Non-Proteinogenic Amino Acids with L-Amino Acid Transaminase: Synthesis of (2S)-2-Amino-4-oxo-4-phenylbutyric and (3E, 2S)-2-Amino-4-phenylbutenoic acids |
| 초록 |
(2S)-2-Amino-4-oxo-4-phenylbutyric and its derivatives are inhibitors of kynurenine-3-hydroxylase and have a potential to be useful as neuroprotective agents. Our present methodology involving aminotransferase catalysed stereospecific transfer of amino group from L-aspartic acid to α-keto acids (our substrates) is very simple and provides products with excellent enantiomeric purity(＞99%)in high yields (68-78%). |
| 저자 |
서수현1, Nitin W. Fadnavis2, 김병기3
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| 소속 |
1School of Chemical Engineering and Institute of Molecular Biology and Genetics, 2Seoul National Univ., 3Indian Institute of Chemical Technology |
| 키워드 |
(2S)-2-Amino-4-oxo-4-phenylbutyric; aromatic amino transferase; L-aspartic acid
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| E-Mail |
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