| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 |
28권 1호, p.261 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Protein Refolding vs Aggregation: Phase Diagram of Concentrated Protein System |
| 초록 |
As an attempt to gain insights that might eventually lead to the development of new ways to avoid or minimize losses due to protein aggregation, we have performed dynamic Monte Carlo simulations on very simple lattice models of systems containing both isolated and multiple protein chains. Model proteins are prepared by sequence annealing method of Shakhnovich and Gutin. Computer simulations are then performed on systems of model proteins in various concentrations to study how the competition between protein refolding and aggregation affects refolding of proteins. The phase diagram of such concentrated protein systems are constructed by using histogram reweighting technique combined with a mean-field theory and the concentration dependence of the stability of native structure is examined in terms of the number of native contacts. |
| 저자 |
이봉재;허준;조원호 |
| 소속 |
서울대 |
| 키워드 |
protein folding; protein aggregation; computer simulation
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| E-Mail |
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