| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 |
27권 2호, p.324 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The unfolding mechanism of model proteins under elongational flow |
| 초록 |
The unfolding of 64-mer model proteins subjected to elongational flow is simulated by a lattice Monte Carlo method. Using enumeration in a fully compact structure and energy spectrum for a given sequence, the sequences of a heteropolymer that show foldability with a unique native structure are selected in sequence space. Conformations of the model proteins undel elongational flow field are then sampled according to Verdier-Stockmayer algorithm. The unfolding pathway of heteropolymers under elongational flow is characterized from the free energy landscape obtained by a histogram method. From the free energy landscape, the pathway of unfolding induced by elongational flow is investigated as a function of the flow rate and compared to that of unfolding induced by other types of external perturbation such as mechanical stretching. |
| 저자 |
이봉재, 허준, 조원호
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| 소속 |
서울대 |
| 키워드 |
protein unfolding; elongational flow; Monte Carlo;
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| E-Mail |
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