| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The synthesis of starch sulfate as an osmotic agent for a new peritoneal dialysis (PD) solution |
| 초록 |
Glucose has been used for 3 decades as an osmotic agent in PD solutions, however it has a serious disadvantages such as short ultrafiltration times, damage to the peritoneum and increasing the glucose concentration in body fluid. In order to overcome these disadvantages, a new high molecular weight osmotic agent, starch sulfate, was synthesized by sulfonation reaction of starch. It was characterized by various measurements such as 1H NMR, FT-IR, SEM and elemental analyzer(EA). According to degree of substitution(DS), the aqueous solubility of starch sulfate was significantly changed. Starch sulfate was dissolved into the water to 8wt%, which had pH 1.0~pH3.0 due to sulfate moiety. Using 1N NaOH and buffering agents for adjusting pH 7.0 and biocompatibility, it shows 128~147mM/L (Na conc.) and 305~405mOsm/L(osmolarity) that is similar to other PD solutions. In case of SD rat experiment, starch sulfate based PD solutions showed a good biocompatibility and ultrafiltration effect. |
| 저자 |
노지영1, 황준석1, 류혜명2, 최순연2, 오은주2, 박선희2, 김용림2, 허강무1
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| 소속 |
1충남대, 2경북대 |
| 키워드 |
starch sulfate; peritoneal dialysis; osmotic agent
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| E-Mail |
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