| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.260 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Sustained release of nifedipine from multi-coated bead containing porous membrane and various excipients |
| 초록 | Such oral drug delivery systems are based on osmosis. Water in medium is diffused throughout the bead, because of osmotic pressure.1 To improve release profile of nifedipine(ND) bead, water absorption force is important. So, we prepared for ND beads by fluidized bed coating.2 Osmotic agent, KCl, was added to the inside of bead to improve water absorption force. So, release rate was increased because of increased osmotic pressure. Also, aging tests were examined for storage. The problem occurred during aging test by plasticizer and was solved by remove plasticizers of liquid type. Finally, the optimal release profile was obtained by bead size, membrane thickness and several excipients. Acknowledgement : This work was supported by KMOCIE (10016482). Reference 1. R.K. Verma, B. Mishra and S. Garg, Osmotically controlled oral drug delivery, Drug Dev. Ind. Pharm. 26, 695, (2000) 2. L. Liu, G. Khang, J.M. Rhee and H.B. Lee, Monolithic osmotic tablet system for nifedipine delivery, J. Control. Release 67, 309, (2000) |
| 저자 | 정성찬1, 전세강2, 조영호2, 최경수2, 이민숙2, 이봉3, 김문석1, 강길선2, 이해방1 |
| 소속 | 1한국화학(연), 2전북대, 3부경대 |
| 키워드 | osmotic; granule; flidized bed coating; cellulose acetate |
