| 초록 |
Many polymer scaffolds are being utilized for regenerating or substituting the damaged tissues and organs in tissue engineering field. Accordingly, such scaffolds must have some properties such as good biocompatibility, suitable biodegradability, and the ability to interact specifically with appropriate cells. These scaffold materials have insufficient initial cell binding sites and limited ability to cell adhesion for in vitro and in vivo tissue culture because of their hydrophobic characteristics. Various efforts are now being attempted to overcome this problems. In this study, the biodegradable 3D dual pore polymer scaffolds were fabricated by using a gas forming technique with nontoxic effervescent salts. The obtained porous scaffolds with hydrophobic surfaces were modified for hydrophilic ones by using plasma glow discharge treatment and some carboxylic acid-containing monomers such as acrylic acid (AA), maleic acid, itaconic acid, and trans-aconitic acid. The surface properties and cell adhesion on hydrophilicity of surface-modified porous scaffolds were compared with unmodified ones.
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