| 초록 |
Although liposuction was originally intended for the removal of undesired fat tissue, it can provide an ideal material for tissue engineering scaffolds. Here we present a biomaterial composed of extracellular matrix (ECM) derived from human fat tissue. The ECM was extracted by successive physical, chemical and enzymatic treatments of human fat tissue isolated by liposuction. Major ECM components were quantified, including collagen, glycosaminoglycan, and elastin. The ECM-based scaffolds were fabricated in a variety of macroscopic shapes such as round dishes, squares, hollow tubes, and beads. In an in vivo experiment using mice, the decellularized ECM graft exhibited good compatibility to surrounding tissues. This scaffold based on human fat tissue holds great promise for many clinical applications in regenerative medicine, particularly in patients requiring soft tissue regeneration. |
