| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Stent surface modifications for strong binding of cell-derived extracellular matrix toward outgrowth endothelial cells delivery |
| 초록 |
In previous study, cobalt-chromium (Co-Cr) surface was modified by introducing a self-assembled monolayer of phosphonic acid (PA-SAM) and fibroblast-derived extracellular matrix (FDM) to deliver outgrowth endothelial cells (OECs). FDM was harvested by decellularizing fibroblasts cultured on the culture plate and was grafted on the PA-SAM-coated Co-Cr. The current study is focused on directly binding FDM on a modified Co-Cr for giving more natural extracellular environment. First, polydopamine (pDA) and fibronectin (FN) were in turn introduced on Co-Cr. It is known that pDA is a strong adhesive molecule and FN robustly binds to ECM components through several binding domains. Herein, FN layer was also strongly bound to the pDA-coated Co-Cr. The tightly immobilized FN is not only suitable for the culture of fibroblasts but also plays a role in holding ECM left after decellularization. This strategy can be a promising method for the formation of a durable OEC layer on a coronary stent. |
| 저자 |
박충원1, 정윤기2, 한동근1
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| 소속 |
1한국과학기술(연), 2과학기술연합대 |
| 키워드 |
coronary stent; polydopamine; fibronectin; extracellular matrix; outgrowth endothelial cells
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| E-Mail |
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