| 학회 |
한국재료학회 |
| 학술대회 |
2010년 가을 (11/11 ~ 11/12, 무주리조트) |
| 권호 |
16권 2호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Activation of macrophages on transparent nano structured titanium |
| 초록 |
The immunotoxicity of implanted nanostructured titanium is a paramount issue for vascular, dental and orthopedic applications. Here, macrophage activation, as evidence of migration, on transparent nanostructured titanium correlated with pro-inflammatory protein synthesis and cytokine release. Through the real-time monitoring of initial cytoskeleton variations, it was identified that macrophage movement was restricted on nano structured titanium compared to flat titanium surfaces. Furthermore, nano structured titanium elicited secretion of less pro-inflammatory enzyme molecules and cytokines, as well as reduced nitric oxide production. All results collectively indicated that initial macrophage activation can be controlled and minimized by nanoscale surface topography alone, without modification of surface chemistry or stiffness. |
| 저자 |
이소영1, 최정일2, 임연민2, 남태현2, 김상현1, 강상수2, 강동우2
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| 소속 |
1경북대, 2경상대 |
| 키워드 |
: immunotoxicity; nanostructured titanium; macrophage activation; live cell recording
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| E-Mail |
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