| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
(정밀화학) 의학 진단 화학 프로브 및 약물 개발 |
| 제목 |
Development of a novel microbubble-liposome complex conjugated with peptide ligands targeting IL4R on brain tumor cells |
| 초록 |
SF6-filled microbubbles were prepared by emulsion and solvent-evaporation method. The prepared MBs were further conjugated with doxorubicin-loaded nano-sized liposome and peptide ligands to interleukin-4 receptor for targeting brain tumor cells. The final MB-Lipo (Dox)-IL4RTP had a spherical structure with the mean size of 1,500 nm. The MB-Lipo (Dox)‑IL4RTP exhibited cellular uptake in U87MG brain tumor cells with frequency ultrasound energy suggesting that MB-Lipo (Dox)‑IL4RTP provided effective targeting ability for brain tumor cells. In addition, WST-1 assay results showed that MB-Lipo (Dox)‑IL4RTP inhibited the proliferation of U87MG cells IL4R‑dependently. This was confirmed by western blotting of γH2AX, phospho (Ser15)-p53, p53 and p21 which are signal transduction proteins involved in DNA damage response and cell cycle arrest. |
| 저자 |
박시형 |
| 소속 |
홍익대 |
| 키워드 |
microbubble; liposome; ligand; IL4R; brain; tumor
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| E-Mail |
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