| 초록 |
Poly (lactic-co-glycolic acid) (PLGA) solid microbeads show superior properties of higher mechanical strengths and durabilities than those of hydrogel microbeads, which makes PLGA microbeads become good candidates as carriers for drug delivery and cell cultivations. To enhance their functionalities in various purposes, in this work, porous PLGA microbeads were synthesized by a modified water-in-oil-in-water (W1/O/W2) double-emulsification solvent evaporation method with incorporation of an effervescent salt in the primary W1 droplets to generate gas bubbles. Finally the organic solvent was perfectly removed by evaporation and the porous PLGA microbeads were harvested after freeze-drying. On account of its simple operation, short time-consuming and quantity production, it becomes a promising and effective method to synthesize highly porous microbeads. The size of microbeads was controlled by the second stirring rate and the concentration of gas-foaming salt. |
