| 학회 | 한국공업화학회 |
| 학술대회 | 2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 | 21권 1호 |
| 발표분야 | 생체재료 |
| 제목 | Self-assembled MPEG-PCL micelles for paclitaxel delivery |
| 초록 | Systemic administration of anti-cancer drug still exhibits several side effects and toxicity such as myelosuppression, mucositis, and alopecia. In this study, we prepared self-assembled micelles with methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (MPEG-PCL) for paclitaxel (PTX) delivery. MPEG-PCL was synthesized by ring-opening polymerization, hydroxyl group of which was substituted to a carboxyl group by succinic anhydride. PTX was then coupled to carboxylated MPEG-PCL through esterification, and micelle was prepared by a solvent evaporation method and its morphology and size distribution were determined, and the effect of the micelles to inhibit the cell growth was investigated with 4T1 cancer cell-line. In vitro test showed that micelles under 200 nm successfully inhibited 4T1 cancer cell growth. Acknowledgment: This research was supported by the grant of ministry of Trade, Industry and Energy (MOTIE) (Grant no. 10047811) |
| 저자 | 이윤성, 김태형, 양대혁, 김재광, 전흥재 |
| 소속 | 가톨릭대 |
| 키워드 | MPEG-PCL; Paclitaxel; Micelle; Chemotherapy; Drug delivery |
