| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Hyaluronic Acid Hydrogels Encapsulating Bio-Coral® As A Novel Artificial Bone Substitute |
| 초록 |
A novel artificial bone substitute for guided bone regeneration was successfully developed using hyaluronic acid (HA) hydrogels encapsulating calcium carbonate (Bio-Coral®). To control the in vivo degradation rate, HA was chemically modified by grafting adipic acid dihydrazide (ADH) to the carboxyl group of HA. Calcium carbonate was in situ encapsulated into the HA-ADH hydrogel during the crosslinking reaction of HA-ADH with bis(sulfosuccinimidyl) suberate (BS3). The resulting hydrogel contained uniformly dispersed calcium carbonate and showed excellent mechanical properties. In vivo test of bone regeneration in rabbit was performed for six months and will be discussed in detail. |
| 저자 |
염준석, 한세광
|
| 소속 |
포항공과대 |
| 키워드 |
Hyaluronic acid; Calcium Carbonate; Hydrogel; Artificial Bone Substitute; Guided Bone regeneration
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| E-Mail |
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