| 초록 |
With the increasing demand for improved quality of life, bio-polymers have been widely used to fabricate diverse biomedical implants. However, in clinical practice, their intended biological performances can be greatly impaired by inappropriate host tissue responses at the implant surface. Herein, we introduce poly(lactic acid) (PLA) and silicone materials for use in orthopedic and breast implant applications, respectively, and modify their surfaces via sputtering-based plasma immersion ion implantation (S-PIII). This technique can implant the most biocompatible metal, tantalum (Ta), on the surface of PLA and silicone and generate nano-textured surface morphologies on both materials without any substrate defects. After S-PIII process, the biologically inert surface chemical properties and high hydrophobicity of PLA and silicone are substantially ameliorated, which leads to significant improvement of in vitro cellular affinity and in vivo host tissue responses. |
