| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Development of a hybrid polymer-silica nanotube as an efficient gene carrier |
| 초록 |
Silica nanotube (SNT) is considered a promising material in biomedical application due to its unique structure. The tube-structured SNTs have two physically distinct domains (inner void and outer surfaces) and can be exploited by functionalizing both the faces separately as per requirements. In this research, we modified a SNT with cationic low molecular weight polyethylenimine and inorganic nanoparticles (iron oxide nanoparticles, quantum dots) separately to utilize it as an efficient gene delivery carrier as well as an imaging agent. It would easily load pDNA and transport the cargo into the cells. Additionally it could be used in tandem for imaging the SNT-internalized cell by magnetic resonance (MR) imaging as well as for monitoring intracellular movement of SNT by fluorescence. |
| 저자 |
남궁란1, Kaushik Singha1, 박인규2, 손상준3, 김원종1
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| 소속 |
1포항공과대, 2전남대, 3경원대 |
| 키워드 |
Gene delivery; Silica nanotube; PEI
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| E-Mail |
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