| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
[정밀화학] 정밀화학 기술 - COVID-19 시대 |
| 제목 |
Nanodiscs as versatile platform for virucide of enveloped viruses |
| 초록 |
The bilayer envelope of viruses is a good target for development of a broad-spectrum antiviral that evokes less resistance while many viral enzyme-inhibiting antivirals results in rapid emergence of resistance due to error-prone replication of viruses. Here, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection. Mechanistically, nanodiscs carrying the viral receptor sialic acid bind to influenza virions and are co-endocytosed into host cells. In contrast, liposomes containing a decoy receptor show weak antiviral activity due to the lack of membrane disruption. Our results suggest a new class of antivirals applicable to other enveloped viruses that cause irreversible physical damage specifically to virus envelope by viruses’ own fusion machine. In conclusion, the lipid nanostructure provides another dimension for antiviral activity of decoy molecules. |
| 저자 |
권대혁 |
| 소속 |
성균관대 |
| 키워드 |
nanodisc; virus; nanoperforator
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| E-Mail |
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