| 초록 |
In the bone regeneration scaffold, the inorganic-organic composite material is easily separated by external force at the interface between the two materials by an external force, and it is difficult to control the exposure to the bioactive material. A hybrid is material that form chemical bonding between organic and inorganic materials, so are expected to have co-decompose with nanoscale interpenetrating networks. However, in the sol-gel process, the hybrid takes several days for gelation, so there is a limitation in manufacturing the porous structure of the scaffold and long manufacturing period. We try to overcome this limitation and maximize the suitability of the hybrid bone scaffold. By increasing the net point of the hybrid, the gelation time of the hybrid is shortened to less than 10 minutes, and the salt leaching method using a porogen was possible. In addition, the Hybrids increase bone regeneration, anti-inflammatory action, and calcification in vitro and in vivo. |
