| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
대학원생 구두발표(토론II): 감염병 대응을 위한 생체 물질 전달용 고분자 연구 |
| 제목 |
Hyaluronated Lipid Nano Particle for mRNA Vaccines |
| 초록 |
In the era of COVID-19, lipid Nano Particle (LNP) has become an important platform for the development of mRNA vaccines. However, the current clinical LNP using poly(ethylene glycol) for mRNA vaccines has been known to cause side effects in a few patients. Here, we developed a hyaluronate (HA) conjugated LNP for mRNA vaccine delivery. Several cationic lipids were conjugated to HA and the resulting HA-LNP conjugates were used to make a complex with eGFP expressing mRNA as a model vaccine. In vitro, HA-LNP/eGFP complex showed the high expression of eGFP by HA receptor mediated endocytosis. In addition, we developed HA-mRNA conjugate to make a complex with LNP for mRNA vaccines. This presentation will address the feasibility of HA-based LNP for the pulmonary delivery of mRNA vaccines. |
| 저자 |
김문구1, 한세광1, 정다함2, 한무현1, 변지윤1, 오승수1
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| 소속 |
1포항공과대, 2(주)화이바이오메드 |
| 키워드 |
Lipid nano particle; Pulmonary delivery; mRNA delivery; Vaccine
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| E-Mail |
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