| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and surface modification of gold nano particles using folic acid for cancer cell imaging |
| 초록 |
High- quality, hydrophilic, uniform, and nontoxic mercapto succinic acid (MA)-coated gold nano particles were prepared and characterized by TEM and DLS. MA was used to improve the biocompatibility, monodispersity and non-specific intracellular uptake of nanoparticles. Folic acid (F) was subsequently conjugated to the MA to preferentially target KB cells (epithelial cancer cells) those have folate receptors expressed on their surfaces and facilitate the transit of nano particles across the cell membrane. Finally, fluorescence isothiocyanate (FITC) was added to the nanoparticles to visualize the nanoparticle internalization into KB cells. After culture of the cells in a media containing the MAGNP and MAGNP-folate conjugate (FMAGNP), the interaction of surface modified gold nano particles with KB cells as studied. |
| 저자 |
피어슨 라씨나라, 강인규, 윤성현, 구태형, 신용석
|
| 소속 |
경북대 |
| 키워드 |
Gold nanoarticles; mercapto succinic acid; folic acid; molecular imaging
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| E-Mail |
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