| 초록 |
Various metal nanostructures and nanoparticles have been developed for more effective molecular detection based on surface-enhanced Raman scattering (SERS). However, it is still challenging to selectively detect target molecules dissolved in complex biological fludis. In this study, we design hydrogel microcylinders containing gold nanoparticles for direct Raman analysis of small molecules in complex mixtures. The microcylinders are fabricated through a micromolding, where hydrogel precursors and gold precursors are confined in cylindrical holes and UV-irraidated. During the photopolymerization of hydrogel precursors, the gold precursor are also photoreduced, resulting in high-density gold nanoparticles embedded in hydrogel matrix. The hydrogel matrix provides molecular size- and charge-selective permeation and the gold nanoparticles selectively show SERS for permeated molecules through the hydrogel. |
