| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
(무기재료) 기능성 무기 나노입자의 합성 및 응용 |
| 제목 |
Molecular Imaging of Drug-Induced Tumor Apoptosis with a Caspase-3/7 Triggered Nanoaggregation Probe |
| 초록 |
In this work, we have developed 18F-labeled and Cy5.5-labeled caspase-3/7 sensitive nanoaggregation probes for in vivo imaging of apoptosis. These probes contain a peptide substrate (Asp-Glu-Val-Asp) which can be cleaved by caspase-3/7. Once it is cleaved by the enzyme in the apoptotic cell, the remaining part undergoes intramolecular cyclization that provides hydrophobic macrocycles. Self-assembly of cyclic monomers can form a large particles by the hydrophobic interaction that results in trapping and enhanced retention of the signal in the apoptotic tumors. Results will be presented that synthesis and labeling procedures of the probes, in vitro evaluation of the labeled probes and specific apoptosis imaging with doxorubicin-treated tumor xenografts.
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| 저자 |
전종호1, Bin Shen2, Mikael Palner3
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| 소속 |
1한국원자력(연), 2Department of Radiology, 3Stanford Univ. |
| 키워드 |
Molecular Imaging; Radiopharmaceuticals; Apoptosis; Enzyme activity
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| E-Mail |
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