| 초록 |
Stimuli sensitive polymersomes made from amphiphilic block copolymer have emerged as promising nanocarriers for the triggered release of many potent anti-cancer drugs. In this study, we have synthesized bioreducible poly(ethylene glycol)-b-poly(lysine)-SS-poly(caprolactone) (PEG-b-PLys-SS-PCL) triblock copolymer via ring opening polymerization of lysine NCA using amine-terminated PEG macro initiator and subsequent conjugation of PCL at the chain end through a disulfide bond. The resulting copolymer was characterized using 1H NMR, fluorescence spectroscopy and dynamic light scattering. Further, doxorubin was encapsulated in to the polymersomes with high drug loading efficiency. The drug was released from the polymersomes in a sustained manner at physiological condition but the release rate is significantly increased at 10 mM glutathione concentration, which is similar to the intracellular environment. |
