| 학회 | 한국화학공학회 |
| 학술대회 | 2015년 봄 (04/22 ~ 04/24, 제주 ICC) |
| 권호 | 21권 1호, p.418 |
| 발표분야 | 생물화공 |
| 제목 | Redox-activated magnetic nanocrystal for accurate T1 and T2 multimodal MR imaging of cancer |
| 초록 | T1/T2 dual-mode magnetic resonance (MR) imaging contrast agents have gained considerable attention because they have the ability to improve accuracy by visualization of two complementary data within one instrument. However, most of those nano-platforms are “always ON” regardless of their interaction with biological targets resulting in poor target-to-background signal ratio. Herein, we introduced an intelligent strategy of paramagnetic relaxation switch (PRS) for dual MR imaging system with enhanced accuracy. Superparamagnetic Fe3O4 nanoparticle was synthesized and coated with Mn3O4 shell through thermal decomposition method, and consecutively surface-modified with polysorbate 80. The Mn3O4 shell acted as not only a protector of core Fe3O4 from aqueous environment for attenuation of T2 relaxation but redoxable PRS activated in intracellular environment. The Mn3O4 of the nanocrystal was reduced to generate large amounts of Mn2+ ions by glutathione (GSH) and allowed interaction of Fe3O4 with protons of water simultaneously. We investigated the OFF/ON operation mechanism of PRS according to GSH levels in solution and human cancer cell line, and confirmed efficiently enhanced T1/T2 relaxivity of the particle. |
| 저자 | 김명훈1, 손혜영2, 허용민2, 함승주1 |
| 소속 | 1연세대, 2연세의료원 |
| 키워드 | dual-mode contrast agent; magnetic resonance imaging; reducing agent; intracellular environment |
| 원문파일 | 초록 보기 |
