| 초록 |
Due to the extreme toxicity of chemical warfare agents (CWAs) containing phosphonate linkages, Sarin (GB), Soman (GD), and VX, their detoxification has been extensively explored. CWAs containing phosphonate and phosphonothioate are insidious—they effectively inhibit the enzyme acetylcholine esterase, shutting down pulmonary muscle control and causing death by oxygen deprivation within minutes. To date, a variety of catalysts has been discovered to be active for the degradation of nerve agents. Among the most promising for the detoxification of CWAs are a class of porous functional materials named metal-organic frameworks (MOFs). In the past few years, tremendous progress have been made in this field including the discovery of zirconium MOF catalysts for fast nerve agent hydrolysis. In this study, I summarize recent advances in the development of MOF catalysts for the hydrolysis of nerve agents. |
