| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Integration of superparamagnetic iron oxide nanoparticles and polyaspartamide for hyperthermia therapy |
| 초록 |
We report a delicate synthesis process of polyaspartamide-encapsulated superparamagnetic iron oxide nanoparticles (PA-SPIONs) for hyperthermia application. SPIONs with a high magnetization have been applied as nano-heaters while PA is a biocompatible and biodegradable polymer with a polysuccinimide (PSI) backbone. Multi-functional polymer PA could be conjugated with other groups such as biotin to enhance the uptake capability by receptors of cancer cells. Consequently, encapsulating SPIONs nano-heaters with PA biopolymer is an attractive roadmap for hyperthermia therapy application. Our results revealed that PA-SPIONs showed excellent biocompatible behavior based on cell viability test. With Prussian blue staining of cancer cells (4T1), cellular uptake of PA-SPIONs was significantly increased in the presence of biotin conjugated on the outer shell. Furthermore, PA-SPIONs exhibited effective cancer killing activities in both in vitro and in vivo hyperthermia experiments. |
| 저자 |
원민프엉, 김덕준
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| 소속 |
성균관대 |
| 키워드 |
iron oxide nanoparticles; polyaspartamide; hyperthermia
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| E-Mail |
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