| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-콜로이드·계면화학 |
| 제목 | pH-Responsive Injectable Tough Tissue Adhesive through Bacterial Cellulose Nanofibril Reinforcement |
| 초록 | Thisstudy introduces a mechanically reinforced mussel-mimetic skin tissue sealingsystem in which a composite hydrogel bioadhesive consisting of bacterialcellulose nanofibers (BCNFs) and boronic acid-conjugated alginate (Al-BA) wasemployed. Boronic acid has a cis-diol moiety that exhibits pH-responsive curingfrom a viscoelastic solution to a soft gel under physiological conditions.However, Al-BA itself has a limitation to tissue suturing due to formation ofintrinsic soft gel phase. Therefore, it is necessary to develop a technology toreinforce the gel phase which has suitable adhesion strength for tissuesealant. For this, we conjugated 3-aminophenylboronic acid onto an alginatebackbone via EDC/NHS-mediated reaction, and then hybridized withBCNFs. Finally, we demonstrated that our bioadhesives exhibited effective skintissue sealing even under wet conditions, thus promising a variety ofbiological applications in the field of tissue engineering. |
| 저자 | 김슬기1, 공현준2, 김진웅1 |
| 소속 | 1성균관대, 2Univ. of Illinois at Urbana-Champaign |
| 키워드 | Tough adhesive; boronic acid; bacterial cellulose nanofiber; tissue sealant |
