| 초록 |
The potential applications of antifreeze proteins (AFPs) have attracted interests in cryopreservation of cells, tissues, drugs, and foods. Metal-organic frameworks (MOFs) nanoparticles (NPs) have properties mimicked from those of AFPs, which can provide periodically arranged ice binding sites through modification of organic linkers. In this study, the zirconium (Zr) was adopted as a metal cluster which is well-dispersed and stable in eco-friendly water solvent. We explored the effect of MOF NPs size on antifreeze activity as the microcurvature of ice surface can be varied by MOF NPs attachment during recrystallization. The specific chemical moiety was simply introduced to acrylate-functionalized MOF NPs to enhance ice recrystallization inhibition. This work provides a strategy for generating the cost-efficient, mass-producible antifreezing nanoagents which can broaden the practical applications to organ transplant, cord blood storage, and vaccine/drug. |
