| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
To characterize a unique diblock copolymers that have functional groups for network gel-forming system. |
| 초록 |
We characterized a unique diblock copolymer network gel-forming system with controllable intra- and intermolecular interactions. FLA was synthesized with a benzyloxymethyl group at the 3-position of the lactide for subsequent derivatization. CL and fLA monomers were randomly copolymerized with varying feed ratios to prepare methoxy polyethylene glycol. PCL-ran-PfLA diblock copolymers. The diblock copolymers with varying PCL and PfLA ratios were further derivatized with benzyl, hydroxyl, or carboxylic acid groups. The MPEG-b-(PCL-ran-PfLA) diblock copolymer solutions exhibited sol-to-gel phase transitions upon a temperature increase which depended on both the type of functional pendant group on the PfLA and the PfLA content in the PCL segment. MCxLy-COOH diblock copolymer solutions immediately formed gels in vivo. and gradually degraded over a period of 0-6 weeks after injection. The MPEG-PCfLA diblock copolymer can be utilized as a potential injectable drug and cell carrier. |
| 저자 |
박지훈, waqas iqbal, 심선우, 권진선, 권두연, 김재호, 김문석
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| 소속 |
아주대 |
| 키워드 |
In situ forming gel; In situ forming gel; Phase transition; MPEG-b-(PCL-ran-PfLA) diblock copolymer; Crystallinity; Hydrophobicity
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| E-Mail |
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