| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
An effective cancer treatment method using folic acid modified bovine serum albumin nanoparticles combining chemo-photodynamic therapy |
| 초록 |
The Doxorubicin (DOX) of chemotherapy has side effects and Chlorin e6 (Ce6) of photodynamic therapy is not effective due to low solubility. We developed the folic acid modified bovine serum albumin-based nanoparticles loaded DOX and Ce6 (FA-Ce6/DOX/BNPs) to solve the problem. Confocal microscopy analysis further validated cellular uptake of FA-Ce6/DOX/BNPs by HeLa cells. Moreover, FA-Ce6/DOX/BNPs potentiated mitochondrial reactive oxygen species (ROS) production in HeLa cells under 671-nm laser exposure, leading to activation of key regulator proteins of apoptosis. Furthermore, we evidenced by gene/protein expression level of apoptotic/anti-apoptotic biomarkers by real time quantitative PCR(RT-qPCR) and western blot analysis. FA-Ce6/DOX/BNPs use in chemo-photodynamic combination therapy with FA as a target cancer cell receptor may provide more effective anti-cancer effects with decreased side effects in cervical cancer. |
| 저자 |
김관우1, 이후민1, Vivek K. Bajpai2, 한영규2, 허윤석1
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| 소속 |
1인하대, 2동국대 |
| 키워드 |
chemotherapy; photodynamic therapy; BNPs
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| E-Mail |
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