| 초록 |
Bone tissue engineering from bone morphogenetic protein (BMP) and stem cells has been developed with various strategies for enhancement of therapeutic effect. However, the engineered bone tissue is still challenging to clinical application because adipose tissue is found together in newly formed bone tissue. Our recent study found that one of bile acid, tauroursodeoxycholic acid (TUDCA), is able to activate osteogenic differentiation from bone marrow mesenchymal stem cells (BMMSCs) followed by enhancement of bone tissue regeneration by reducing adipose tissue. Therefore, would be a potential alternative drug for bone tissue regeneration in pharmacologic and therapeutic applications. In this presentation, I would like to introduce various approach of bile acid for tissue regeneration. |
