| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
177Lu-Labeled Cyclic-Cholecystokinin Derivative for Peptide-Receptor Radionuclide Therapy |
| 초록 |
Radionuclide-labeled peptides have been designed to target the receptors which are over-expressed in cancer cells. In particular, the Cholecystokinin(CCK) receptor has been shown to be overexpressed in various cancer cells. In the present study, a cyclic-CCK derivative was designed to investigate its tumor-targeting ability in AR42J human pancreatic cancer cells. The cyclic-CCK, DOTA-Nle-cyclo(Glu-Trp-Nle-Asp-Phe-Lys-NH2) was synthesized by a solid phase synthesis method, and radiolabeled with 177Lu. The radiolabeled peptide was effectively accumulated in the AR42J tumor in vivo. It was concluded that cyclic-CCK derivative can be a potential candidate as a targeting modality for the CCK receptor overexpressing cancers. |
| 저자 |
조은하, 임재청, 이소영, 도소희, 김수용, 정성희
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| 소속 |
한국원자력(연) |
| 키워드 |
PRRT; Radioisotope; Lung cancer; Peptide
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| E-Mail |
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